Mice and rats are usually quite gentle and can be handled without much trouble. Feistier pets can be picked up and restrained by grasping the base of the tail with one hand and as you lift, encircling the back and ribcage with the other hand. For mice, you can also use your thumb and index finger to grasp the scruff of the neck. Be ready: Most rodents will urinate and/or defecate when handled.
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